P-279 A rare subset of well-differentiated gastro-entero-pancreatic neuroendocrine tumors with positive FDG PET/CT: Is it a sign of an aggressive disease?
نویسندگان
چکیده
Neuroendocrine tumors (NETs) are relatively rare and heterogeneous, mostly asymptomatic discovered incidentally. PET-CT is one of the gold diagnostic standards typically detects well-differentiated NETs using 68Gallium-Dotatate (Ga-PET/CT) more aggressive undifferentiated 18F-FDG (FDG-PET/CT). However, some displaying atypical high-grade features being detected on FDG-PET/CT. In this study, we aim to study role FDG-PET/CT in patients with gastro-entero-pancreatic (GEP) NETs, positive uptake A retrospective chart review all GEP cases diagnosed, from 2014 2021, at American University Beirut Medical Center was done. Patients who have low (G1) or intermediate (G2) findings were included based WHO classification Ki 67 ≤2 for grade >2-≤20 NETs. Out 36 G1 G2 NET diagnosed during that period, 9 (25%) met inclusion criteria study. Median age diagnosis 60 years, 6 (66%) males. 8 (88.9%) both Ga-PET/CT positive, while 1 (11.1%) negative. had 2 disease. All metastatic disease except patient locally advanced The tumor originated small bowels pancreas remaining 3 (33%). As initial treatment after diagnosis, received octreotide, capecitabine temozolomide, octreotide underwent surgical resection, everolimus, temozolomide Whipple procedure. 5 progression plan. FDG-PET/CT, median free survival (PFS) 40.1 months (95% CI, 15.4 – 64.9) mean PFS 36.2 23.1 49.2). these significantly lower reported literature G1/G2 negative (36.2 vs 71 months, p = 0.0162). FDG PET/CT shorter than literature. Should include prognostic score?.
منابع مشابه
Neuroendocrine tumors of the gastro-entero-pancreatic system.
Gastro-entero-pancreatic (GEP) neuroendocrine tumors (NETs) are rare neoplasms, although their prevalence has increased substantially over the past three decades. Moreover, there has been an increased clinical recognition and characterization of these neoplasms. They show extremely variable biological behavior and clinical course. Most NETs have endocrine function and secrete peptides and neuro...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2022
ISSN: ['0923-7534', '1569-8041']
DOI: https://doi.org/10.1016/j.annonc.2022.04.368